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Article

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus.

Human molecular genetics - 1 Feb 2015

Acevedo Nathalie, Reinius Lovisa E, Greco Dario, Gref Anna, Orsmark-Pietras Christina, Persson Helena, Pershagen Göran, Hedlin Gunilla, Melén Erik, Scheynius Annika, Kere Juha, Söderhäll Cilla

Abstract excerpt

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA methylation and mRNA levels of GSDMB and ORMDL3. Genetic association between GSDMB/ORMDL3 and physician-diagnosed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25256354
DOI: 10.1093/hmg/ddu479
PMCID: PMC4291244

Genes

ORMDL3
GSDMB
IKZF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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