Article
A systems approach identifies networks and genes linking sleep and stress: implications for neuropsychiatric disorders.
Cell reports - 5 May 2015
Jiang Peng, Scarpa Joseph R, Fitzpatrick Karrie, Losic Bojan, Gao Vance D, Hao Ke, Summa Keith C, Yang He S, Zhang Bin, Allada Ravi, Vitaterna Martha H, Turek Fred W, Kasarskis Andrew
Abstract excerpt
Sleep dysfunction and stress susceptibility are comorbid complex traits that often precede and predispose patients to a variety of neuropsychiatric diseases. Here, we demonstrate multilevel organizations of genetic landscape, candidate genes, and molecular networks associated with 328 stress and sleep traits in a chronically stressed population of 338 (C57BL/6J × A/J) F2 mice. We constructed striatal gene...
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