Article
Gene networks associated with conditional fear in mice identified using a systems genetics approach.
BMC systems biology - 16 Mar 2011
Park Christopher C, Gale Greg D, de Jong Simone, Ghazalpour Anatole, Bennett Brian J, Farber Charles R, Langfelder Peter, Lin Andy, Khan Arshad H, Eskin Eleazar, Horvath Steve, Lusis Aldons J, Ophoff Roel A, Smith Desmond J
Abstract excerpt
BACKGROUND: Our understanding of the genetic basis of learning and memory remains shrouded in mystery. To explore the genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity panel (HMDP) with high mapping resolution. RESULTS: A total of 27 behavioral quantitative trait loci were mapped with a false discovery rate of 5%. By integrating...
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