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Article

Social isolation-induced transcriptomic changes in mouse hippocampus impact the synapse and show convergence with human genetic risk for neurodevelopmental phenotypes.

PloS one - 1 Jan 2023

Laighneach Aodán, Kelly John P, Desbonnet Lieve, Holleran Laurena, Kerr Daniel M, McKernan Declan, Donohoe Gary, Morris Derek W

Abstract excerpt

Early life stress (ELS) can impact brain development and is a risk factor for neurodevelopmental disorders such as schizophrenia. Post-weaning social isolation (SI) is used to model ELS in animals, using isolation stress to disrupt a normal developmental trajectory. We aimed to investigate how SI affects the expression of genes in mouse hippocampus and to investigate how these changes related to the genetic basis...

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Identifiers

PMID: 38127959
DOI: 10.1371/journal.pone.0295855
PMCID: PMC10735045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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