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Article

A Combined Analysis of Genetically Correlated Traits Identifies Genes and Brain Regions for Insomnia.

Canadian journal of psychiatry. Revue canadienne de psychiatrie - 1 Dec 2020

Liu Kezhi, Zhu Ling, Yu Minglan, Liang Xuemei, Zhang Jin, Tan Youguo, Huang Chaohua, He Wenying, Lei Wei, Chen Jing, Gu Xiaochu, Xiang Bo

Abstract excerpt

AIMS: Previous studies have inferred that there is a strong genetic component in insomnia. However, the etiology of insomnia is still unclear. This study systematically analyzed multiple genome-wide association study (GWAS) data sets with core human pathways and functional networks to detect potential gene pathways and networks associated with insomnia. METHODS: We used a novel method, multitrait analysis of...

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PMID: 32648482
DOI: 10.1177/0706743720940547
PMCID: PMC7658420

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