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Article

Cross-species systems analysis identifies gene networks differentially altered by sleep loss and depression.

Science advances - 1 Jul 2018

Scarpa Joseph R, Jiang Peng, Gao Vance D, Fitzpatrick Karrie, Millstein Joshua, Olker Christopher, Gotter Anthony, Winrow Christopher J, Renger John J, Kasarskis Andrew, Turek Fred W, Vitaterna Martha H

Abstract excerpt

To understand the transcriptomic organization underlying sleep and affective function, we studied a population of (C57BL/6J × 129S1/SvImJ) F2 mice by measuring 283 affective and sleep phenotypes and profiling gene expression across four brain regions. We identified converging molecular bases for sleep and affective phenotypes at both the single-gene and gene-network levels. Using publicly available transcriptomic...

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Source

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Identifiers

PMID: 30050989
DOI: 10.1126/sciadv.aat1294
PMCID: PMC6059761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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