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Article

Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.

Nature genetics - 1 Aug 2022

Watanabe Kyoko, Jansen Philip R, Savage Jeanne E, Nandakumar Priyanka, Wang Xin, Hinds David A, Gelernter Joel, Levey Daniel F, Polimanti Renato, Stein Murray B, Van Someren Eus J W, Smit August B, Posthuma Danielle

Abstract excerpt

Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing...

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PMID: 35835914
DOI: 10.1038/s41588-022-01124-w

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