Article
Identification of causal genes, networks, and transcriptional regulators of REM sleep and wake.
Sleep - 1 Nov 2011
Millstein Joshua, Winrow Christopher J, Kasarskis Andrew, Owens Joseph R, Zhou Lili, Summa Keith C, Fitzpatrick Karrie, Zhang Bin, Vitaterna Martha H, Schadt Eric E, Renger John J, Turek Fred W
Abstract excerpt
STUDY OBJECTIVE: Sleep-wake traits are well-known to be under substantial genetic control, but the specific genes and gene networks underlying primary sleep-wake traits have largely eluded identification using conventional approaches, especially in mammals. Thus, the aim of this study was to use systems genetics and statistical approaches to uncover the genetic networks underlying 2 primary sleep traits in the...
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