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Article

Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid Ligands.

Trends in biochemical sciences - 1 Aug 2018

Salter Jason D, Smith Harold C

Abstract excerpt

The 11-member APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of zinc-dependent cytidine deaminases bind to RNA and single-stranded DNA (ssDNA) and, in specific contexts, modify select (deoxy)cytidines to (deoxy)uridines. In this review, we describe advances made through high-resolution co-crystal structures of APOBECs bound to mono- or oligonucleotides that reveal potential...

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Identifiers

PMID: 29803538
DOI: 10.1016/j.tibs.2018.04.013
PMCID: PMC6073885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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