Article
High-Level Pan-Azole-Resistant Aspergillosis.
Journal of clinical microbiology - 1 Jul 2015
van Ingen Jakko, van der Lee Henrich A L, Rijs Antonius J M M, Snelders Eveline, Melchers Willem J G, Verweij Paul E
Abstract excerpt
High-level pan-azole-resistant Aspergillus fumigatus was recovered from four patients with chronic lung disease. In one patient, the development of progressive resistance followed long-term azole therapy and switching between antifungal azoles. The high-level pan-azole-resistant phenotypes were not associated with a specific cyp51A gene mutation. New strategies that avoid the development of progressive azole...
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