Article
Emergence of Azole Resistance in Aspergillus.
Seminars in respiratory and critical care medicine - 1 Oct 2015
Wiederhold Nathan P, Patterson Thomas F
Abstract excerpt
Resistance to the azole antifungals itraconazole, voriconazole, and posaconazole in Aspergillus species is a growing concern. This is especially alarming for A. fumigatus, where acquired resistance has been documented in patients with invasive disease caused by this species that were exposed to these agents, as well as in azole-naive individuals. The primary mechanisms of resistance that have been described in...
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