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Article

Rapid induction of multiple resistance mechanisms in Aspergillus fumigatus during azole therapy: a case study and review of the literature.

Antimicrobial agents and chemotherapy - 1 Jan 2012

Camps Simone M T, van der Linden Jan W M, Li Yi, Kuijper Ed J, van Dissel Jaap T, Verweij Paul E, Melchers Willem J G

Abstract excerpt

Nine consecutive isogenic Aspergillus fumigatus isolates cultured from a patient with aspergilloma were investigated for azole resistance. The first cultured isolate showed a wild-type phenotype, but four azole-resistant phenotypes were observed in the subsequent eight isolates. Four mutations were found in the cyp51A gene of these isolates, leading to the substitutions A9T, G54E, P216L, and F219I. Only G54...

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Identifiers

PMID: 22005994
DOI: 10.1128/AAC.05088-11
PMCID: PMC3256077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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