Article
Passive surveillance for azole-resistant Aspergillus fumigatus, United States, 2011-2013.
Emerging infectious diseases - 1 Sept 2014
Pham Cau D, Reiss Errol, Hagen Ferry, Meis Jacques F, Lockhart Shawn R
Abstract excerpt
Emergence of Aspergillus fumigatus strains containing mutations that lead to azole resistance has become a serious public health threat in many countries. Nucleotide polymorphisms leading to amino acid substitutions in the lanosterol demethylase gene (cyp51A) are associated with reduced susceptibility to azole drugs. The most widely recognized mutation is a lysine to histidine substitution at aa 98 (L98H) and a...
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