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Development of Azole Resistance in Aspergillus fumigatus during Azole Therapy Associated with Change in Virulence

9 Apr 2010

Abstract excerpt

Four sequential Aspergillus fumigatus isolates from a patient with chronic granulomatous disease (CGD) eventually failing azole-echinocandin combination therapy were investigated. The first two isolates (1 and 2) were susceptible to antifungal azoles, but increased itraconazole, voriconazole and posaconazole MICs were found for the last two isolates (3 and 4). Microsatellite typing showed that the 4 isolates were...

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PMID: 20404915
DOI: 10.1371/journal.pone.0010080

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