Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Combination of CYP51A Mutations Confers Pan-Azole Resistance in Aspergillus fumigatus.

Antimicrobial agents and chemotherapy - 22 Jul 2020

Macedo Daiana, Brito Devoto Tomás, Pola Santiago, Finquelievich Jorge L, Cuestas María L, Garcia-Effron Guillermo

Abstract excerpt

The treatment of invasive and chronic aspergillosis involves triazole drugs. Its intensive use has resulted in the selection of resistant isolates, and at present, azole resistance in Aspergillus fumigatus is considered an emerging threat to public health worldwide. The aim of this work is to uncover the molecular mechanism implicated in the azole resistance phenotype of three Aspergillus fumigatus clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Argentina

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aspergillus fumigatus

Share to Azoles

Share to Cytochrome P-450 Enzyme System

Share to Drug Resistance, Fungal

Share to Fungal Proteins

Share to Microbial Sensitivity Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 32423948
DOI: 10.1128/AAC.02501-19
PMCID: PMC7526825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Combination of CYP51A Mutations Confers Pan-Azole Resistance in Aspergillus fumigatus.PMID 32423948Read ↗

Azole-resistant Aspergillus fumigatus isolates carrying TR₃₄/L98H mutations in Taiwan.Semantic proximity Read ↗

cyp51A-Based mechanisms of Aspergillus fumigatus azole drug resistance present in clinical samples from Germany.Semantic proximity Read ↗

Azole-resistant Aspergillus fumigatus as an emerging worldwide pathogen.Semantic proximity Read ↗

Examination of cyp51A and cyp51B expression level of the first Polish azole resistant clinical Aspergillus fumigatus isolateSemantic proximity Read ↗

High prevalence of triazole-resistant Aspergillus fumigatus sensu stricto in an Argentinean cohort of patients with cystic fibrosis.Semantic proximity Read ↗

Multiple cyp51A-based mechanisms identified in azole-resistant isolates of Aspergillus fumigatus from China.Semantic proximity Read ↗

Azole Resistance and cyp51A Mutation of Aspergillus fumigatus in a Tertiary Referral Hospital in TaiwanSemantic proximity Read ↗

Moving beyond multi-triazole to multi-fungicide resistance: Broader selection of drug resistance in the human fungal pathogen Aspergillus fumigatusSemantic proximity Read ↗

High prevalence of clinical and environmental triazole-resistant Aspergillus fumigatus in Iran: is it a challenging issue?Semantic proximity Read ↗

Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms.Semantic proximity Read ↗

Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus FungiSemantic proximity Read ↗

A Cyp51B Mutation Contributes to Azole Resistance in Aspergillus fumigatusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.