Article
High detection rate of azole-resistant Aspergillus fumigatus after treatment with azole antifungal drugs among patients with chronic pulmonary aspergillosis in a single hospital setting with low azole resistance.
Medical mycology - 6 Apr 2021
Takeda Keita, Suzuki Junko, Watanabe Akira, Arai Teppei, Koiwa Tomohiro, Shinfuku Kyota, Narumoto Osamu, Kawashima Masahiro, Fukami Takeshi, Tamura Atsuhisa, Nagai Hideaki, Matsui Hirotoshi, Kamei Katsuhiko
Abstract excerpt
The prevalence of azole-resistant Aspergillus fumigatus (ARAF) among chronic pulmonary aspergillosis (CPA) patients treated with azoles in Japan is unknown. The aim of this study was to determine the detection rate of ARAF in isolates from CPA patients who were treated with azoles for varying durations. The potential mechanism of acquiring resistance was examined by sequencing cyp51A and hmg1, two genes...
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