Article
Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.
Emerging infectious diseases - 1 Jun 2015
van der Linden J W M, Arendrup M C, Warris A, Lagrou K, Pelloux H, Hauser P M, Chryssanthou E, Mellado E, Kidd S E, Tortorano A M, Dannaoui E, Gaustad P, Baddley J W, Uekötter A, Lass-Flörl C, Klimko N, Moore C B, Denning D W, Pasqualotto A C, Kibbler C, Arikan-Akdagli S, Andes D, Meletiadis J, Naumiuk L, Nucci M, Melchers W J G, Verweij P E
Abstract excerpt
To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use...
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