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Article

Multiple cyp51A-based mechanisms identified in azole-resistant isolates of Aspergillus fumigatus from China.

Antimicrobial agents and chemotherapy - 1 Jul 2015

Liu Musang, Zeng Rong, Zhang Lili, Li Dongmei, Lv Guixia, Shen Yongnian, Zheng Hailin, Zhang Qiangqiang, Zhao Jingjun, Zheng Nan, Liu Weida

Abstract excerpt

Seventy-two A. fumigatus clinical isolates from China were investigated for azole resistance based on mutations of cyp51A. We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34/L98H/S297T/F495I mutation, while one carries only the TR34/L98H mutation. To our knowledge, the latter has not been found previously in China. The...

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Identifiers

PMID: 25896700
DOI: 10.1128/AAC.00003-15
PMCID: PMC4468671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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