Article
A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis.
The pharmacogenomics journal - 1 Apr 2016
Julià A, Fernandez-Nebro A, Blanco F, Ortiz A, Cañete J D, Maymó J, Alperi-López M, Fernández-Gutierrez B, Olivè A, Corominas H, Erra A, Acosta-Colman I, Alonso A, López-Lasanta M, Tortosa R, Tornero J, Marsal S
Abstract excerpt
Anti-Tumor Necrosis Factor (anti-TNF) drugs are biologic agents commonly used to treat rheumatoid arthritis (RA). However, anti-TNFs are not effective in approximately one out of four treated patients. We conducted a Genome-Wide Association Study (GWAS) to identify the genetic variation associated with the response to anti-TNF therapy in RA. In the discovery stage, 372 RA patients treated with an anti-TNF agent...
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