Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts.

doi:10.3389/fimmu.2021.672255

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Article

Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts.

Frontiers in immunology - 1 Jan 2021

Sánchez-Maldonado Jose Manuel, Cáliz Rafael, López-Nevot Miguel Ángel, Cabrera-Serrano Antonio José, Moñiz-Díez Ana, Canhão Helena, Ter Horst Rob, Quartuccio Luca, Sorensen Signe B, Glintborg Bente, Hetland Merete L, Filipescu Ileana, Pérez-Pampin Eva, Conesa-Zamora Pablo, Swierkot Jerzy, den Broeder Alfons A, De Vita Salvatore, Petersen Eva Rabing Brix, Li Yang, Ferrer Miguel A, Escudero Alejandro, Netea Mihai G, Coenen Marieke J H, Andersen Vibeke, Fonseca João E, Jurado Manuel, Bogunia-Kubik Katarzyna, Collantes Eduardo, Sainz Juan

Abstract excerpt

We aimed to validate the association of 28 GWAS-identified genetic variants for response to TNF inhibitors (TNFi) in a discovery cohort of 1361 rheumatoid arthritis (RA) patients monitored in routine care and ascertained through the REPAIR consortium and DANBIO registry. We genotyped selected markers and evaluated their association with response to TNFi after 6 months of treatment according to the change in...

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PMID: 34777329
DOI: 10.3389/fimmu.2021.672255
PMCID: PMC8579100

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