Article
A longitudinal genome-wide association study of anti-tumor necrosis factor response among Japanese patients with rheumatoid arthritis.
Arthritis research & therapy - 18 Jan 2016
Honne Kyoko, Hallgrímsdóttir Ingileif, Wu Chunsen, Sebro Ronnie, Jewell Nicholas P, Sakurai Takeo, Iwamoto Masahiro, Minota Seiji, Jawaheer Damini
Abstract excerpt
BACKGROUND: Studies of Caucasian patients with rheumatoid arthritis (RA) to identify genetic biomarkers of anti-tumor necrosis factor (TNF) response have used response at a single time point as the phenotype with which single nucleotide polymorphism (SNP) associations have been tested. The findings have been inconsistent across studies. Among Japanese patients, only a few SNPs have been investigated. We report...
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