Article
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2000
Liu Chunyu, Batliwalla Franak, Li Wentian, Lee Annette, Roubenoff Ronenn, Beckman Evan, Khalili Houman, Damle Aarti, Kern Marlena, Furie Richard, Dupuis Josée, Plenge Robert M, Coenen Marieke J H, Behrens Timothy W, Carulli John P, Gregersen Peter K
Abstract excerpt
The prediction of response (or non-response) to anti-TNF treatment for rheumatoid arthritis (RA) is a pressing clinical problem. We conducted a genome-wide association study using the Illumina HapMap300 SNP chip on 89 RA patients prospectively followed after beginning anti-TNF therapy as part of Autoimmune Biomarkers Collaborative Network (ABCoN [Autoimmune Bio-markers Collaborative Network]) patient cohort....
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