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Article

VPS13D Gene Variant Is Associated with Altered IL-6 Production and Mortality in Septic Shock.

Journal of innate immunity - 1 Jan 2015

Nakada Taka-aki, Boyd John H, Russell James A, Aguirre-Hernández Rosalía, Wilkinson Mark D, Thair Simone A, Nakada Emiri, McConechy Melissa K, Fjell Christopher D, Walley Keith R

Abstract excerpt

BACKGROUND: Genetic variations contribute to septic shock mortality. To discover a novel locus, we performed in vitro genome-wide association studies (GWAS) and further tested the result in a cohort of septic shock patients. METHODS: Two in vitro GWAS using a quantitative trait locus analysis of stimulated IL-6 production in lymphoblastoid cells from 60 individuals of European ancestry were performed. VPS13D...

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PMID: 25896417
DOI: 10.1159/000381265
PMCID: PMC6738836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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