Article
The interleukin-6 (IL6)-174 G/C promoter genotype is associated with the presence of septic shock and the ex vivo secretion of IL6.
International journal of immunogenetics - 1 Dec 2007
Tischendorf J J W, Yagmur E, Scholten D, Vidacek D, Koch A, Winograd R, Gressner A M, Trautwein C, Wasmuth H E, Lammert F
Abstract excerpt
Septic shock is associated with a high mortality and an excessive activation of immune cascades. Interleukin (IL)-6 has been found to be a key cytokine in the pathogenesis of severe sepsis, but the importance of a regulatory polymorphism within the IL6 promoter has been controversial in these patients. The aim of the study was therefore to systematically investigate the IL6-174 G/C promoter genotype with regard...
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