Article
Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer.
International journal of molecular sciences - 29 May 2021
Rosier Florian, Brisebarre Audrey, Dupuis Claire, Baaklini Sabrina, Puthier Denis, Brun Christine, Pradel Lydie C, Rihet Pascal, Payen Didier
Abstract excerpt
The high mortality rate in septic shock patients is likely due to environmental and genetic factors, which influence the host response to infection. Two genome-wide association studies (GWAS) on 832 septic shock patients were performed. We used integrative bioinformatic approaches to annotate and prioritize the sepsis-associated single nucleotide polymorphisms (SNPs). An association of 139 SNPs with death based...
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