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Article

Identification of a nonsynonymous polymorphism in the SVEP1 gene associated with altered clinical outcomes in septic shock.

Critical care medicine - 1 Jan 2015

Nakada Taka-aki, Russell James A, Boyd John H, Thair Simone A, Walley Keith R

Abstract excerpt

OBJECTIVES: Mortality from septic shock is highly heritable. The identification of causal genetic factors is insufficient. To discover key contributors, we first identified nonsynonymous single-nucleotide polymorphisms in conserved genomic regions that are predicted to have significant effects on protein function. We then test the hypothesis that these nonsynonymous single-nucleotide polymorphisms across the...

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Source

Identifiers

PMID: 25188548
DOI: 10.1097/CCM.0000000000000604

Genes

SVEP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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