Article
A genome-wide association study of survival in patients with sepsis.
Critical care (London, England) - 5 Nov 2022
Hernandez-Beeftink Tamara, Guillen-Guio Beatriz, Lorenzo-Salazar Jose M, Corrales Almudena, Suarez-Pajes Eva, Feng Rui, Rubio-Rodríguez Luis A, Paynton Megan L, Cruz Raquel, García-Laorden M Isabel, Prieto-González Miryam, Rodríguez-Pérez Aurelio, Carriedo Demetrio, Blanco Jesús, Ambrós Alfonso, González-Higueras Elena, Espinosa Elena, Muriel Arturo, Tamayo Eduardo, Martin María M, Lorente Leonardo, Domínguez David, de Lorenzo Abelardo García, Giannini Heather M, Reilly John P, Jones Tiffanie K, Añón José M, Soro Marina, Carracedo Ángel, Wain Louise V, Meyer Nuala J, Villar Jesús, Flores Carlos
Abstract excerpt
BACKGROUND: Sepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in adult intensive care units. Most genetic studies have identified gene variants associated with development and outcomes of sepsis focusing on biological candidates. We conducted the first genome-wide association study (GWAS) of 28-day survival in adult patients with...
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