Article
Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome.
American journal of physiology. Lung cellular and molecular physiology - 1 Oct 2013
Sun Xiaoguang, Ma Shwu-Fan, Wade Michael S, Acosta-Herrera Marialbert, Villar Jesús, Pino-Yanes Maria, Zhou Tong, Liu Bin, Belvitch Patrick, Moitra Jaideep, Han Yoo-Jeong, Machado Roberto, Noth Imre, Natarajan Viswanathan, Dudek Steven M, Jacobson Jeffrey R, Flores Carlos, Garcia Joe G N
Abstract excerpt
The genetic mechanisms underlying the susceptibility to acute respiratory distress syndrome (ARDS) are poorly understood. We previously demonstrated that sphingosine 1-phosphate (S1P) and the S1P receptor S1PR3 are intimately involved in lung inflammatory responses and vascular barrier regulation. Furthermore, plasma S1PR3 protein levels were shown to serve as a biomarker of severity in critically ill ARDS...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.