Article
Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality.
EBioMedicine - 1 Oct 2016
Scherag André, Schöneweck Franziska, Kesselmeier Miriam, Taudien Stefan, Platzer Matthias, Felder Marius, Sponholz Christoph, Rautanen Anna, Hill Adrian V S, Hinds Charles J, Hossain Hamid, Suttorp Norbert, Kurzai Oliver, Slevogt Hortense, Giamarellos-Bourboulis Evangelos J, Armaganidis Apostolos, Trips Evelyn, Scholz Markus, Brunkhorst Frank M
Abstract excerpt
Sepsis is the dysregulated host response to an infection which leads to life-threatening organ dysfunction that varies by host genomic factors. We conducted a genome-wide association study (GWAS) in 740 adult septic patients and focused on 28day mortality as outcome. Variants with suggestive evidence for an association (p≤10-5) were validated in two additional GWA studies (n=3470) and gene coding regions related...
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