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Article

Genetic Variation in MAP3K1 Associates with Ventilator-Free Days in Acute Respiratory Distress Syndrome.

American journal of respiratory cell and molecular biology - 1 Jan 2018

Morrell Eric D, O'Mahony D Shane, Glavan Bradford J, Harju-Baker Susanna, Nguyen Catherine, Gunderson Scott, Abrahamson Aaron, Radella Frank, Rona Gail, Black R Anthony, Wurfel Mark M

Abstract excerpt

Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) regulates numerous intracellular signaling pathways involved in inflammation and apoptosis. We hypothesized that genetic variation in MAP3K1 might be associated with outcomes in patients with acute respiratory distress syndrome (ARDS), and that these variants would alter MAP3K1-mediated changes in inflammation and transcriptional regulation. To test this...

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Identifiers

PMID: 28858533
DOI: 10.1165/rcmb.2017-0030OC
PMCID: PMC5941309

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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