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Article

IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis.

Critical care (London, England) - 1 Jan 2011

Nakada Taka-aki, Russell James A, Boyd John H, Walley Keith R

Abstract excerpt

INTRODUCTION: Interleukin 17A (IL17A) plays a key role in host defense against microbial infection including Gram-positive bacteria. Genetic factors contribute to the host defense, but the role of IL17A single nucleotide polymorphisms (SNPs) has not yet been investigated in severe sepsis. Therefore, we hypothesized that SNPs in the IL17A gene alter susceptibility to infection and clinical outcome of severe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22026963
DOI: 10.1186/cc10515
PMCID: PMC3334805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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