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Discovery of human-like L-asparaginases with potential clinical use by directed evolution

25 Aug 2017

Abstract excerpt

Abstract L-asparaginase is a chemotherapy drug used to treat acute lymphoblastic leukemia (ALL). The main prerequisite for clinical efficacy of L-asparaginases is micromolar K M for asparagine to allow for complete depletion of this amino acid in the blood. Since currently approved L-asparaginases are of bacterial origin, immunogenicity is a challenge, which would be mitigated by a human enzyme. However, all...

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PMID: 28860480
DOI: 10.1038/s41598-017-10758-4

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