Structures of Apo and Product-Bound Human <scp>l</scp>-Asparaginase: Insights into the Mechanism of Autoproteolysis and Substrate Hydrolysis

Abstract excerpt

Asparaginases catalyze the hydrolysis of the amino acid asparagine to aspartate and ammonia. Bacterial asparaginases are used in cancer chemotherapy to deplete asparagine from the blood, because several hematological malignancies depend on extracellular asparagine for growth. To avoid the immune response against the bacterial enzymes, it would be beneficial to replace them with human asparaginases. However,...

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