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Article

Sequencing, identification and mapping of primed L1 elements (SIMPLE) reveals significant variation in full length L1 elements between individuals.

BMC genomics - 21 Mar 2015

Streva Vincent A, Jordan Vallmer E, Linker Sara, Hedges Dale J, Batzer Mark A, Deininger Prescott L

Abstract excerpt

BACKGROUND: There are over a half a million copies of L1 retroelements in the human genome which are responsible for as much as 0.5% of new human genetic diseases. Most new L1 inserts arise from young source elements that are polymorphic in the human genome. Highly active polymorphic "hot" L1 source elements have been shown to be capable of extremely high levels of mobilization and result in numerous instances of...

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Identifiers

PMID: 25887476
DOI: 10.1186/s12864-015-1374-y
PMCID: PMC4381410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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