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Article

Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.

Molecular neurodegeneration - 11 Mar 2015

Xiang Wei, Menges Stefanie, Schlachetzki Johannes Cm, Meixner Holger, Hoffmann Anna-Carin, Schlötzer-Schrehardt Ursula, Becker Cord-Michael, Winkler Jürgen, Klucken Jochen

Abstract excerpt

BACKGROUND: Aggregation and aggregation-mediated formation of toxic alpha synuclein (aSyn) species have been linked to the pathogenesis of sporadic and monogenic Parkinson's disease (PD). A novel H50Q mutation of aSyn, resulting in the substitution of histidine by glutamine, has recently been identified in PD patients. We have previously shown that the lipid peroxidation product 4-hydroxy-2-nonenal (HNE) induces...

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Identifiers

PMID: 25886189
DOI: 10.1186/s13024-015-0004-0
PMCID: PMC4365527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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