Article

Glycation modulates glutamatergic signalling and exacerbates Parkinson’s disease-like phenotypes

2021-08-25

Abstract excerpt

Alpha-synuclein (aSyn) is assumed to be a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson’s disease and, one common molecular alteration among these disorders is an age-associated increase in protein glycation. Thus...

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Literature Corpus work: 3b134eaa-3c0d-5bef-9f80-db658e319d84
DOI: 10.1101/2021.08.24.457507

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