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Article

N-terminal acetylation mutants affect alpha-synuclein stability, protein levels and neuronal toxicity.

Neurobiology of disease - 1 Apr 2020

Vinueza-Gavilanes Rodrigo, Íñigo-Marco Ignacio, Larrea Laura, Lasa Marta, Carte Beatriz, Santamaría Enrique, Fernández-Irigoyen Joaquín, Bugallo Ricardo, Aragón Tomás, Aldabe Rafael, Arrasate Montserrat

Abstract excerpt

Alpha-synuclein (aSyn) protein levels are sufficient to drive Parkinson's disease (PD) and other synucleinopathies. Despite the biomedical/therapeutic potential of aSyn protein regulation, little is known about mechanisms that limit/control aSyn levels. Here, we investigate the role of a post-translational modification, N-terminal acetylation, in aSyn neurotoxicity. N-terminal acetylation occurs in all aSyn...

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Identifiers

PMID: 31991248
DOI: 10.1016/j.nbd.2020.104781

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