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Article

Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics

2 Jan 2017

Abstract excerpt

Copper is one of the metals described to bind the Parkinson disease-related protein α-synuclein (aSyn), and to promote its aggregation. Although histidine at position 50 in the aSyn sequence is one of the most studied copper-anchoring sites, its precise role in copper binding and aSyn aggregation is still unclear. Previous studies suggested that this residue does not significantly affect copper-mediated aSyn...

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PMID: 28289488
DOI: 10.1080/19420889.2016.1270484

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