Neuronal Oxidative Stress Promotes α-Synuclein Aggregation In Vivo

Abstract excerpt

Both genetic and environmental factors increase risk for Parkinson’s disease. Many of the known genetic factors influence α-synuclein aggregation or degradation, whereas most of the identified environmental factors produce oxidative stress. Studies using in vitro approaches have identified mechanisms by which oxidative stress can accelerate the formation of α-synuclein aggregates, but there is a paucity of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neurological disorders and treatments
• Share to Nuclear Receptors and Signaling
• Share to Parkinson's Disease Mechanisms and Treatments