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Increased Oxidative Stress Exacerbates α-Synuclein Aggregation In Vivo

27 Apr 2018

Abstract excerpt

Increasing evidence suggests a relationship between oxidative stress and α-synuclein aggregation, the primary pathological hallmark of Parkinson disease (PD). However, a direct causal relationship has not yet been established in vivo in mouse models of PD. Superoxide dismutase 2 (SOD2) is rate limiting in the antioxidant machinery of the mitochondria and even its partial deficiency elevates oxidative stress in...

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PMID: 29718367
DOI: 10.1093/jnen/nly024

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