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Article

Vascular dysfunction and increased metastasis of B16F10 melanomas in Shb deficient mice as compared with their wild type counterparts.

BMC cancer - 8 Apr 2015

Zang Guangxiang, Gustafsson Karin, Jamalpour Maria, Hong JongWook, Genové Guillem, Welsh Michael

Abstract excerpt

BACKGROUND: Shb is a signaling protein downstream of vascular endothelial growth factor receptor-2 and Shb deficiency has been found to restrict tumor angiogenesis. The present study was performed in order to assess metastasis in Shb deficiency using B16F10 melanoma cells. METHODS: B16F10 melanoma cells were inoculated subcutaneously on wild type or Shb +/- mice. Primary tumors were resected and lung metastasis...

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Source

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Identifiers

PMID: 25885274
DOI: 10.1186/s12885-015-1269-y
PMCID: PMC4392795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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