Article
The vascular phenotype of melanoma metastasis.
Clinical & experimental metastasis - 1 Jan 2003
Velazquez Omaida C, Herlyn Meenhard
Abstract excerpt
Melanoma cells but not normal melanocytes share important cell surface molecules with endothelial cells. From this observation has grown our hypothesis that melanoma and endothelial cells use the same cell surface molecules for invasion but that their intracellular signaling is different allowing the malignant cells dominance over the normal cells. Stromal fibroblasts and endothelial cells communicate with...
Topics
- Cell Communication
- Endothelium, Vascular
- Fibroblasts
- Hematopoietic Stem Cells
- Humans
- Melanoma
- Neovascularization, Pathologic
- Phenotype
- Signal Transduction
- Skin Neoplasms