Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2005

Brantley-Sieders Dana M, Fang Wei Bin, Hicks Donna J, Zhuang Guanglei, Shyr Yu, Chen Jin

Abstract excerpt

EphA2 belongs to a unique family of receptor tyrosine kinases that play critical roles in development and disease. Since EphA2 is required for ephrin-A1 ligand-induced vascular remodeling and is overexpressed in a variety of vascularized human adenocarcinomas, we assessed tumor angiogenesis and metastatic progression in EphA2-deficient host animals. 4T1 metastatic mammary adenocarcinoma cells transplanted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transplantation
Share to In Situ Nick-End Labeling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Laminin

Share to Mammary Neoplasms, Animal

Share to Microcirculation

Share to Platelet Endothelial Cell Adhesion Molecule-1

Share to Proteoglycans

Share to rac1 GTP-Binding Protein

Source

Identifiers

PMID: 16166198
DOI: 10.1096/fj.05-4038fje

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression.PMID 16166198Read ↗

Generation of transgenic mice overexpressing EfnB2 in endothelial cells.Semantic proximity Read ↗

Ets2 in Tumor Fibroblasts Promotes Angiogenesis in Breast CancerSemantic proximity Read ↗

Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor GrowthSemantic proximity Read ↗

EphA2 Receptor Tyrosine Kinase as a Promising Target for Cancer TherapeuticsSemantic proximity Read ↗

EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation.Semantic proximity Read ↗

FOXC2 promotes vasculogenic mimicry and resistance to anti-angiogenic therapySemantic proximity Read ↗

The ephrins and Eph receptors in angiogenesis.Semantic proximity Read ↗

Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions.Semantic proximity Read ↗

Switching of vascular phenotypes within a murine breast cancer model induced by angiopoietin-2.Semantic proximity Read ↗

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.Semantic proximity Read ↗

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.Semantic proximity Read ↗

Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.