Article

Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

2020-10-07

Abstract excerpt

The tyrosine phosphatase SHP2 is oncogenic in cancers driven by receptor-tyrosine-kinases, and SHP2 inhibition reduces tumor growth. Here, we report that SHP2 is an essential promoter of endothelial cell survival and growth in the remodeling tumor vasculature. Using genetic and chemical approaches to inhibit SHP2 activity in endothelial cells, we show that SHP2 inhibits pro-apoptotic STAT3 and stimulates prolifera...

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Literature Corpus work: ff7fd28e-2e9c-5fd7-bc29-434f623e5287
DOI: 10.1101/2020.10.06.327882

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