Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development.

Journal of the National Cancer Institute - 2 Aug 2006

Young Neville, Hahn Christopher N, Poh Alisa, Dong Carolyn, Wilhelm Dagmar, Olsson Jane, Muscat George E O, Parsons Peter, Gamble Jennifer R, Koopman Peter

Abstract excerpt

BACKGROUND: The growth of solid tumors depends on establishing blood supply; thus, inhibiting tumor angiogenesis has been a long-term goal in cancer therapy. The SOX18 transcription factor is a key regulator of murine and human blood vessel formation. METHODS: We established allograft melanoma tumors in wild-type mice, Sox18-null mice, and mice expressing a dominant-negative form of Sox18 (Sox18RaOp) (n = 4 per...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High Mobility Group Proteins

Share to Platelet Endothelial Cell Adhesion Molecule-1

Share to Proteoglycans

Share to SOXF Transcription Factors

Share to Transplantation, Homologous

Share to Umbilical Veins

Source

Identifiers

PMID: 16882943
DOI: 10.1093/jnci/djj299

Genes

SOX18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development.PMID 16882943Read ↗

Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice.Semantic proximity Read ↗

SOX9 reactivation in cancer vessels shapes the tumor micro-environment through hypoxia and immune depletion promoting tumor growth and metastasisSemantic proximity Read ↗

SOX18 and the transcriptional regulation of blood vessel development.Semantic proximity Read ↗

Inhibition of tumor angiogenesis by cell-permeable dominant negative SOX18 mutants.Semantic proximity Read ↗

VEGFD regulates blood vascular development by modulating SOX18 activitySemantic proximity Read ↗

Construction and functional analysis of novel dominant-negative mutant of human SOX18 protein.Semantic proximity Read ↗

Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in ZebrafishSemantic proximity Read ↗

Sox18 induces development of the lymphatic vasculature in miceSemantic proximity Read ↗

Expression of human SOX18 in normal tissues and tumors.Semantic proximity Read ↗

Sox18 and Sox7 play redundant roles in vascular development.Semantic proximity Read ↗

Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasisSemantic proximity Read ↗

Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.