Article
Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders.
Journal of cellular and molecular medicine - 1 Dec 2008
Brüggemann Lois W, Versteeg Henri H, Niers Tatjana M, Reitsma Pieter H, Spek C Arnold
Abstract excerpt
Experimental animal studies as well as clinical trials have shown that interventions targeting the blood coagulation cascade inhibit cancer cell metastasis. These data support the hypothesis that congenital prothrombotic disorders, like factor V Leiden, facilitate metastasis whereas bleeding disorders, like haemophilia impede metastasis. To test this hypothesis, we subjected factor V Leiden and factor VIII...
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