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Article

High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients.

Journal of translational medicine - 5 Dec 2024

Di Mauro Annabella, Santorsola Mariachiara, Savarese Giovanni, Sirica Roberto, Ianniello Monica, Cossu Alessia Maria, Ceccarelli Anna, Sabbatino Francesco, Bocchetti Marco, Carratù Anna Chiara, Pentimalli Francesca, Ferrara Gerardo, Nasti Guglielmo, Caraglia Michele, Ottaiano Alessandro

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI) is a well-established predictive biomarker for immune checkpoint inhibitor (ICI) response in metastatic colon cancer. Both high MSI and tumor mutational burden (TMB) are markers of genomic instability. However, the prognostic and predictive value of TMB in patients with microsatellite stable (MSS) tumors remains unclear. METHODS: We evaluated the prognostic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39639373
DOI: 10.1186/s12967-024-05927-9
PMCID: PMC11619254

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