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Article

Genomic and immunological features of microsatellite instability in colon cancer.

Gene - 20 May 2021

Luo Yi, Yang Zhou, Chen Yusheng, Lu Xiaolan, Quan Yingjun

Abstract excerpt

Microsatellite instability (MSI) is closely related to the prognosis and therapy response of colon cancer. Colon cancer patients with MSI show resistance to 5-Fluorouracil (5-FU) but sensitivity to immunosuppressive checkpoint inhibitors (ICIs). The relevant mechanism behind the opposite response remains unclear. Multi-omics research data of colon cancer patients were acquired from The Cancer Genome Atlas (TCGA)...

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Identifiers

PMID: 33636290
DOI: 10.1016/j.gene.2021.145534

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