Article
Comprehensive analysis of copy number aberrations in microsatellite stable colon cancer in view of stromal component.
British journal of cancer - 25 Jul 2017
Alonso M Henar, Aussó Susanna, Lopez-Doriga Adriana, Cordero David, Guinó Elisabet, Solé Xavier, Barenys Mercè, de Oca Javier, Capella Gabriel, Salazar Ramón, Sanz-Pamplona Rebeca, Moreno Victor
Abstract excerpt
BACKGROUND: Somatic copy number aberrations (CNAs) are common acquired changes in cancer cells having an important role in the progression of colon cancer (colorectal cancer, CRC). This study aimed to perform a characterisation of CNA and their impact in gene expression. METHODS: Copy number aberrations were inferred from SNP array data in a series of 99 CRC. Copy number aberration events were calculated and used...
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