Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites

Abstract excerpt

BACKGROUND: Psoriasis is a cytokine-mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited for treating mild psoriasis. To develop more targeted therapies, interfering with transcription factor (TF) activity is a promising strategy. METHODS: Meta-analysis was used to identify...

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